Mitochondrial DNA Haplogroups and Age-Related Maculopathy

Mitochondrial DNA haplogroups and age-related hearing loss.

OBJECTIVE To determine whether variants of the mitochondrial genome influence the risk of developing age-related hearing loss (ARHL). DESIGN Cross-sectional study. SETTING Eligible participants were noninstitutionalized permanent residents 49 years or older identified in a door-to-door census of 2 suburban postcode areas, west of Sydney, Australia. PARTICIPANTS The Blue Mountains Hearing ...

Mitochondrial DNA haplogroups associated with age-related macular degeneration.

PURPOSE To examine the mtDNA control regions in normal and age-related macular degeneration (AMD) retinas. To identify the mtDNA variations associated with AMD. METHODS Retinas from 10 normal and 11 AMD globes were isolated and analyzed for mtDNA rearrangements by long extension-polymerase chain reaction (LX-PCR) and for the nature and frequency of single-nucleotide polymorphisms (SNPs) in th...

Epidemiology of age-related maculopathy.

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Mitochondrial Haplogroups and Well Defined Populations

Macular carotenoids and age-related maculopathy.

Lutein (L) and zeaxanthin (Z) are concentrated at the macula, where they are collectively known as macular pigment (MP), and where they are believed to play a major role in protecting retinal tissues against oxidative stress. Whilst the exact pathogenesis of age-related maculopathy (ARM) remains unknown, the disruption of cellular processes by oxidative stress may play an important role. Manipu...